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How to take Plenvu

Read our guide below which explains how to take Plenvu.

You can also download a PDF version of this patient information by following the link on the right.

What is Plenvu?Ā®

It’s a polyethylene glycol (PEG) laxative designed to cleanse your bowel prior to your planned colonoscopy. It does this by causing you to have diarrhoea, or frequent bowel movements. You’ll start passing brown liquid and this will gradually change into a clear/yellowish liquid.

A clean bowel will allow a clear view of the inner lining which is important for accurate diagnosis and treatment.

Please ensure you follow the instructions carefully. We may need to cancel the colonoscopy and repeat it at another time if the bowel isn’t clean enough.

If you think you are not fit enough to go backwards and forwards to the toilet many times to have your bowel open, then do not start to take this medication and get in touch with the doctor or team who referred you for this test for further advice.

Before taking Plenvu? Ā®

You need to follow a low fibre diet for 3 days before taking PlenvuĀ®. Please see the ‘low fibre diet‘ leaflet for details of the type of diet you need to follow before taking PlenvuĀ®.

PlenvuĀ® is a two-dose preparation.
Dose 1 is a single mango-flavoured sachet.
Dose 2 is two sachets (A and B) fruit punch flavoured.
All sachets must be taken with the right amount of water according to the timing.

Oral medication should NOT be taken within one hour of taking PlenvuĀ® as it may not be absorbed properly ā€“ please see the table below:

Iron Tablets Stop 7 days prior to taking PlenvuĀ®
Anticoagulants and anti-platelets (Blood thinning medication)

Warfarin, Apixaban, Rivaroxiban, Dabigatran, Edoxaban, Aspirin, Dipyridamole, Clopidogrel, Ticagrelor, Cangrelor or Prasugrel

If you take any of this type of medication, please inform the booking team who makes your appointment so they can arrange a pre-assessment consultation and advise you on what to do in preparation for your test. Booking team:

01296 – 831210

Insulin controlled
diabetes patients
Please see supplementary information sheet and contact your Diabetes Specialist Nurse/ or GP Practice Nurse for further advice if required. Glucose energy drinks and glucose tablets if sucked can be taken for hypoglycaemia.


You will need to manage a reduction in your normal insulin dose during bowel preparation and until after your procedure

Oral anti-diabetes tablets Please see supplementary information sheet and contact your Practice Nurse at your GP surgery for further advice if required. Absorption of tablets may be affected by the PlenvuĀ®.
Diet controlled diabetes patients No action required


Booking team:

01296 – 831210


Anti-epileptics, oral contraceptives, antibiotic and oral anti-diabetic medication Bowel cleansing may interfere with normal absorption of these drugs. Contact the Medicines Resource Centre for further advice.
Anti-diarrhoeal tablets Stop 3 days prior to taking PlenvuĀ®

Important – Do not take PlenvuĀ® if …? Ā 

  • Your condition has significantly changed since you were referred for this treatment or if you have developed any of the following symptoms listed below. Instead, you should contact the Endoscopy unit at which you are booked to have your procedure for further advice.
  • If it is possible that you are pregnant
  • Heart failure
  • If you have had a heart attack (within the last 6 weeks)
  • Kidney failure
  • Difficulty in swallowing
  • Severe breathing problems
  • If you have been told you have a stomach or bowel blockage
  • You have had recent bowel surgery (within the last 6 weeks)
  • If you have been told you have active diverticulitis (this means that you will have pain and a doctor may have given you antibiotics)

Making up PlenvuĀ®

PlenvuĀ® may be easier to take if:

  • You drink through a straw.
  • It has been refrigerated after it has been made up
  • It is sipped slowly rather than drinking it quickly

Making up PlenvuĀ® dose 1

You should make up PlenvuĀ® Dose 1 when you need it, based on your dosing schedule (see below).


Making up PlenvuĀ® dose 2

How to take PlenvuĀ®

The timing of your PlenvuĀ® doses depends on whether you are having a morning (before 12.00 noon), afternoon (after 1pm) appointment. Please follow the relevant row on the timeline below depending upon your appointment time. Stop eating by the time shown on the timeline.

Clear fluids may be taken until 2 hours before the procedure.

Suggested fluids include water, cordial, squash (not blackcurrant) or herbal tea of your choice ā€“ these need to be taken after each sachet of PlenvuĀ®.

After taking PlenvuĀ®

  • Use a barrier cream to prevent a ā€˜sore bottomā€™, e.g. petroleum jelly
  • Make sure you allow enough time to travel to the hospital for your colonoscopy
  • Consider using wet wipes after each bowel movement.Ā  Wet wipes that have been refrigerated are particularly soothing.